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Giganta is depicted as a scientist named Dr. Doris Zeul who gains the ability to grow to giant size and superhuman strength after being exposed to an experimental serum. She becomes a formidable opponent for the Justice League and is often hired as a mercenary for her size and strength. Despite her villainous actions, she is depicted as having a tragic backstory and a desire for revenge against those who wronged her in the past. Throughout the series, Giganta clashes with various members of the Justice League, including Wonder Woman and The Flash, and is often depicted as a pawn in larger schemes by other villains. Despite her fearsome reputation, she also forms alliances with other villains and even has a romantic relationship with another villain, Gorilla Grodd.